Journal
JOURNAL OF IMMUNOLOGY
Volume 179, Issue 6, Pages 3596-3603Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.179.6.3596
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- NIAID NIH HHS [P30 AI060354] Funding Source: Medline
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IL-21, a member of the common gamma-chain family of cytokines, has pleiotropic effects on T, B, and NK cells. We found that IL-21 and the prototype common gamma-chain cytokine IL-2 can stimulate proliferation and cytokine secretion by Ag-specific rhesus monkey CD8(+) T cells. However, unique among the members of this family of cytokines, we found that IL-21 drives these cells to apoptosis by down-regulation of Bcl-2. These findings suggest that IL-21 may play an important role in the contraction of CD8(+) T cell responses.
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