Journal
BIOLOGICAL PSYCHIATRY
Volume 62, Issue 6, Pages 694-697Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2006.11.018
Keywords
alcohol; drinking; family history; naltrexone
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Funding
- NCRR NIH HHS [M01 RR 00125] Funding Source: Medline
- NIAAA NIH HHS [P50 AA 12870] Funding Source: Medline
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Background: The purpose of this study was to examine the interactive effects of family history of alcoholism (FH+, FH-) and naltrexone dose (0, 50, 100 mg/day) on alcohol drinking. Methods: Ninety-two, non-treatment-seeking alcohol-dependent participants received naltrexone daily for 6 days. On the 6th day, they participated in a laboratory paradigm involving exposure to a priming dose of alcohol followed by a 2-hour drinking period in which they made choices between consuming alcoholic drinks and receiving money. Results: Total number of drinks consumed during the drinking period was significantly decreased by the 100-mg dose of naltrexone in FH+ drinkers. Secondary analyses in male drinkers (n = 70) indicated that 100 mg of naltrexone significantly decreased drinking in FH+ participants and increased drinking in FH - drinkers. Conclusions: These results suggest that family history of alcoholism might be a significant clinical predictor of response to naltrexone and that FH+ men are more likely to benefit from naltrexone therapy for alcohol drinking.
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