Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 15, Issue 18, Pages 6236-6241Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2007.06.022
Keywords
methicillin-resistant Staphylococcus aureus (MRSA); Antibacterial; Anacardic acid analogue; 6-(4',8'-Dimethylnonyl)salicylic acid
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A series of anacardic acid analogues possessing different side chains viz. phenolic, branched, and alicyclic were synthesized and their antibacterial activity tested against methicillin-resistant Staphylococcus aureus (MRSA). The maximum activity against this bacterium occurred with the branched side-chain analogue, 6-(4',8'-dimethylnonyl)salicylic acid, and the alicyclic side-chain analogue, 6-cyclododecylmethyl salicylic acid, with the minimum inhibitory concentration (MIC) of 0.39 mu g/mL, respectively. This activity was superior to that of the most potent antibacterial anacardic acid isolated from the cashew Anacardium occidentale (Anacardiaceae), apple and nut, that is, the 6-[8'(Z), 11'(Z), 14'-pentadecatrienyl]salicylic acid. (c) 2007 Elsevier Ltd. All rights reserved.
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