Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 260, Issue 1-2, Pages 271-274Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2007.04.021
Keywords
frontal-lobe syndorome; frontal-subcortical circuits; hallucinations; mesocorticolimbic dopaminergic system; rostral brainstem
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A patient developed frontal-lobe syndrome and psychotic symptoms after infarction in the pontomesencephalic junction. Stereotaxic lesion localization on magnetic resonance imaging and statistical analyses of regional cerebral blood flow (rCBF) disclosed an involvement of the rostral brainstern dopaminergic nuclei and hypoperfusion in the frontal-subcortical circuit components. We suggest that the patient's cognitive and behavioral disturbances were associated with disruption of ascending dopaminergic projections to the frontal-subcortical circuits. (c) 2007 Elsevier B.V. All rights reserved.
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