Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 196, Issue 6, Pages 812-816Publisher
UNIV CHICAGO PRESS
DOI: 10.1086/520818
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Funding
- NIAID NIH HHS [AI056423, AI057168] Funding Source: Medline
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A female adult cat developed clinical disease 13 days after subcutaneous inoculation with Nipah virus (NiV) and was discovered to be pregnant at necropsy. Viral genome was detected in a variety of specimens, including blood, serum, tonsil swabs, and urine, up to 3 days before the onset of disease. Samples collected postmortem, including placenta, uterine fluid, and fetal tissues, were also positive for NiV genome, and the placenta and uterine fluid contained high levels of recoverable virus. The high levels of viral shedding in the adult combined with fetal viral replication suggests that both vertical and horizontal transmission of NiV could play a role in spillover events, an essential element in the epidemiology of Henipavirus infection.
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