Journal
SYNLETT
Volume -, Issue 15, Pages 2347-2350Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2007-985595
Keywords
alpha-hydroxy phosphonates; Abramov reaction; water; Amberlyst-15; nucleophilic addition
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An efficient and simple synthesis of u-hydrcxy phosplionates has been achieved via reaction of aldehydes with tri-methylphosphite in the presence of Amberlyst-15 in water. The reaction is highly selective with excellent yields under mild conditions.
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