Journal
VACCINE
Volume 25, Issue 37-38, Pages 6774-6783Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2007.06.052
Keywords
bluetongue; capripoxvirus; vaccine
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The development of recombinant capripoxviruses for protective immunization of ruminants against bluetongue virus (BTV) infection is described. Sheep (n = 11) and goats (n = 4) were immunized with BTV recombinant capripoxviruses (BTV-Cpox) individually expressing four different genes encoding two capsid proteins (VP2 and VP7) and two non-structural proteins (NS1, NS3) of BTV serotype 2 (BTV-2). Seroconversion was observed against NS3, VP7 and VP2 in both species and a lymphoproliferation specific to BTV antigens was also demonstrated in goats. Finally, partial protection of sheep challenged 3 weeks after BTV-Cpox administration with a virulent strain of BTV-2, was observed. (c) 2007 Elsevier Ltd. All rights reserved.
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