Journal
ADVANCED MATERIALS
Volume 19, Issue 18, Pages 2492-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.200700029
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An interfacial peptide coating possessing domains that bind to Ti and endothelial cells is synthesized (see figure). Peptides with specific adherence to Ti are identified using phage display, and the RGD motif was selected for cell binding. The peptide can be applied from aqueous solution and possesses micromolar binding affinities. The coating significantly enhances endothelial cell adhesion and spreading under both static and dynamic conditions.
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