Journal
CANCER LETTERS
Volume 255, Issue 1, Pages 57-70Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2007.03.023
Keywords
CapG; gelsolin; siRNA; invasion; cell aggregation; cytoskeleton; cancer cell
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Gelsolin and CapG are both actin binding proteins that modulate a variety of physiological processes by interacting differently with the actin cytoskeleton. Several studies suggest that overexpression of these proteins promotes invasion in vitro. In this study we explored the contribution of these proteins in human cancer cell invasion and motility. We show that down regulation of CapG or gelsolin in several types of cancer cells, including MDA-MB 231 and PC-3 cells, significantly reduces the invasive and motile properties of cells, as well as cell aggregation. These results point to a role for CapG and gelsolin as tumor activator. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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