Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 55, Issue 19, Pages 7753-7757Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf0711486
Keywords
biotransformation; peroxiclase; resveratrol; ferulic acid; cardiac cell injury
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Peroxidase extracted from Momordica charantia was used for the oligomerization of trans-resveratrol and ferulic acid on a preparative scale. One new heterocoupling oligomer, trans-3E-3-[(4-hydroxy3-methoxyphenyl)methylene]-4-(3,5-dihydroxyphenyl)-5-(4-hydroxyphenyl)tetrahydro-2-franone (6), and six resveratrol dimers, leachianol G (1), restrytisol B (2), parthenostilbenins A (3) and B (5), 7-O-acetylated leachianol G (4), and resveratrol trans-dehydrodimer (8), and one known ferulic acid dehydrodimer, (3 alpha,3a alpha,6 alpha,6a alpha)tetrahydro-3,6-bis(4-hydroxy-3-methoxyphenyl)-1 H,4H-furo[3,4-c]furan1,4-dione (7) were obtained. Bioactive experiments showed that compounds 6-8 have strong free radical scavenging effects and also have protective effects on doxorubicin-induced cardiac cell injury when tested in vitro.
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