Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 129, Issue 37, Pages 11346-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja073965s
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Funding
- NCI NIH HHS [N01-CO-12400, CA59021] Funding Source: Medline
- NIMH NIH HHS [R21MH076146] Funding Source: Medline
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Small-molecule microarrays have been used to discover biologically active small molecules in collections of synthetic compounds. Here we utilize a versatile isocyanate chemistry to immobilize extracts from microorganisms in a microarray format. Specific bioactive small molecules are detected in crude extracts of Streptomyces hygroscopicus, and the amount of specific to nonspecific binding of a protein to an immobilized compound on a microarray can be estimated. These natural product-extract microarrays (NPEMs) provide new tools for characterizing the metabolic products of organisms and for discovering biologically active small molecules from nature.
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