4.8 Article

Intramolecular Heck reactions of unactivated alkyl halides

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 129, Issue 37, Pages 11340-+

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja075245r

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Funding

  1. NIGMS NIH HHS [R01-GM62871] Funding Source: Medline

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A method has been developed for achieving palladium-catalyzed intramolecular Heck reactions of unactivated, beta-hydrogen-containing alkyl bromides and chlorides. The data from a stereochemical investigation are consistent with carbon-carbon bond formation via an alkylpalladium, rather than a radical, intermediate.

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