Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 45, Issue 1, Pages 145-148Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jpba.2007.04.016
Keywords
yunaconitine; crassicauline A; foresaconitine; SPE; LC-MS-MS
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A sensitive method has been developed for the identification and quantification of the toxic alkaloids yunaconitine, crassicauline A, and foresaconitine in urine specimens. After solid-phase extraction using Oasis(R) MCX cartridges, the extracts were analyzed by LC-MS-MS. The limit of detection is 0.03 ng/mL urine for yunaconitine and 0.05 ng/mL urine for crassicauline A and foresaconitine; the limit of quantitation is 0.15 ng/mL urine for yunaconitine and 0.20 ng/mL urine for crassicauline A and foresaconitine. The method was employed in the analysis of the urine of a 55-year-old male who died after ingestion of herbal medicine powder made from the roots of aconite. Yunaconitine, crassicauline A and foresaconitine were identified in the urine. Crassicauline A and foresaconitine were thus identified in a biological specimen for the first time. (C) 2007 Elsevier B.V. All rights reserved.
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