Journal
LANCET
Volume 370, Issue 9592, Pages 1089-1100Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0140-6736(07)61305-1
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Funding
- PHS HHS [5 K23 D K071565] Funding Source: Medline
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Psychological stress elicits measurable changes in sympathetic-parasympathetic balance and the tone of the hypothalamic-pituitary-adrenal axis, which might negatively affect the cardiovascular system both acutely-by precipitating myocardial infarction, left-ventricular dysfunction, or dysrhythmia; and chronically-by accelerating the atherosclerotic process. We provide an overview of the association between stress and cardiovascular morbidity, discuss the mechanisms for this association, and address possible therapeutic implications.
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