Gold-catalyzed hydroamination/cycloisomerization reaction of 1,6-enynes

An efficient Au(l) catalytic system is described for the hydroamination/cycloisomerization reaction of functionalized 1,6-enynes. The reaction leads to carbo- and heterocyclic amino derivatives in good to excellent yields. The cyclizations were conducted in the presence of PPh3- AuCl/AgSbF6 catalyst in THF or dioxane at room temperature. The use of allyloxycarbonyl carbamate has allowed the formation of free amino derivatives via sequential Au- and Pd-catalyzed reactions.