Journal
ORGANIC LETTERS
Volume 9, Issue 20, Pages 3869-3872Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol071342d
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We report here the enantioselective carbonyl-ene reactions of various 1,1-disubstituted and trisubstituted alkenes with ethyl glyoxylate. The reactions are catalyzed by a new Co-salen complex, in which bulky triisobutylsilyl (TIBS) substituents occupy the positions ortho to the phenolic oxygens. This complex catalyzes the reactions under nearly ideal conditions-at room temperature and using catalyst loadings as low as 0.1 mol %-and provides the chiral, homoallylic alcohol products in excellent yields, enantioselectivities, and diastereoselectivities.
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