Journal
TETRAHEDRON-ASYMMETRY
Volume 18, Issue 19, Pages 2300-2304Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2007.09.020
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The combination of (Sa)-binam-L-Pro (5 mol %) and benzoic acid (10 mol %) was used as catalysts in the direct aldol reaction between diff. erent aliphatic ketones and 4-nitrobenzaldehyde under solvent-free reaction conditions. Three diff. erent procedures are assayed: magnetic stirring (method A), magnetic stirring after previous dissolution in THF and evaporation (method B), and ball mill technique (method C), methods A and B being the simplest. These reaction conditions allowed us to reduce the amount of required ketone to 2 equiv to give the aldol product in similar reaction times and regio-, diastero-, and enantioselectivities than in organic or aqueous solvents. (c) 2007 Elsevier Ltd. All rights reserved.
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