Journal
MOLECULES
Volume 12, Issue 10, Pages 2348-2363Publisher
MDPI
DOI: 10.3390/12102348
Keywords
antitumor; cytotoxicity; mass spectrometry; multinuclear NMR; organotin
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A series of mono-, di- and triorganotin compounds with general formulae [RSnL2Cl], R = Bu ( compound 3), [R2SnL2], where R = Me, Et, Bu, Oct ( compounds 1, 2, 4 and 6) and [R3SnL], where R = Bu, Cy and Ph ( compounds 5, 7 and 8) and where L = 3,4-methylenedioxy-6-nitrophenylpropenoic acid have been prepared and characterized by elemental analysis, multinuclear (H-1-, C-13- and Sn-119-) NMR and mass spectrometry. The ligand and its respective organotin complexes were screened for cytotoxicity using the brine shrimp lethality assay and for antitumor activity using the crown gall tumor inhibition ( potato disc) assay. The bioassay results support the conclusion that the biological activities of these synthetic compounds are in the following order: [ RSnL2Cl] < [ R2SnL2] < [ R3SnL].
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