Journal
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
Volume 155, Issue 2, Pages 84-93Publisher
ELSEVIER
DOI: 10.1016/j.molbiopara.2007.06.002
Keywords
Schistosoma mansoni; egg secretome; egg secreted proteins; MudPIT proteomics
Categories
Funding
- NIAID NIH HHS [R03 AI059037, R03 AI059037-02, R03 AI059037-01, R03AI059037, N01-AI-55270, R03 AI055270] Funding Source: Medline
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Schistosomiasis remains a largely neglected, global health problem. The morbid pathology of the disease stems from the host's inflammatory response to parasite eggs trapped in host tissues. Long term host/parasite survival is dependent upon the successful modulation of the acute pathological response, which is induced by egg antigens. In this study, using Multidimensional Protein Identification Technology, we identified the Schistosoma mansoni egg secretome consisting of 188 proteins. Notably we identified proteins involved in redox balance, molecular chaperoning and protein folding, development and signaling, scavenging and metabolic pathways, immune response modulation, and 32 novel, previously uncharacterized schistosome proteins. We localized a subset of previously characterized schistosome proteins identified in egg secretions in this study, to the surface of live S. mansoni eggs using the circumoval precipitin reaction. The identification of proteins actively secreted by live schistosome eggs provides important new information for understanding immune modulation and the pathology of schistosomiasis. (c) 2007 Elsevier B.V. All rights reserved.
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