Journal
FISH & SHELLFISH IMMUNOLOGY
Volume 23, Issue 4, Pages 781-792Publisher
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fsi.2007.02.006
Keywords
CpG; rainbow trout; adjuvant; bacterial challenge; lysozyme; chemoattractant
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The effects of unmethylated CpG oligodeoxynucleotides (ODN) on the mammalian immune system are relatively well studied but much less is known of their effects on the immune systems of different fish species. Here we show that CpG ODNs significantly enhance the survival of rainbow trout (Oncorhynchus mykiss) following bacterial challenge when used both as stand-alone prophylactic agents, or as adjuvants to a commercially available vaccine. They are also capable of increasing serum lysozyme activity in vivo and stimulating the production of chemoattractant factors for rainbow trout head kidney (HK) leucocytes in vitro. (c) 2007 Elsevier Ltd. All rights reserved.
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