Journal
PATTERN RECOGNITION LETTERS
Volume 28, Issue 13, Pages 1781-1787Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.patrec.2007.05.008
Keywords
segmentation; voting level set; voronoi; subcellular localization; nuclear segmentation; 3D cell culture assay
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Funding
- NCI NIH HHS [U54 CA112970-029002] Funding Source: Medline
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Blob-like structures occur often in nature, where they aid in cueing and the pre-attentive process. These structures often overlap, form perceptual boundaries, and are heterogeneous in shape, size, and intensity. In this paper, voting, Voronoi tessellation, and level set methods are combined to delineate blob-like structures. Voting and subsequent Voronoi tessellation provide the initial condition and the boundary constraints for each blob, while curve evolution through level set formulation provides refined segmentation of each blob within the Voronoi region. The paper concludes with the application of the proposed method to a dataset produced from cell based fluorescence assays and stellar data. (c) 2007 Elsevier B.V. All rights reserved.
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