Journal
ANNALS OF THE RHEUMATIC DISEASES
Volume 66, Issue 10, Pages 1271-1275Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/ard.2006.062927
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Funding
- NCRR NIH HHS [M01 RR000048, RR00048] Funding Source: Medline
- NIAMS NIH HHS [R01 AR046225, R01 AR46225, P60 AR48098] Funding Source: Medline
- PHS HHS [R01 48748] Funding Source: Medline
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Background: A greater knee adduction moment increases risk of medial tibiofemoral osteoarthritis (OA) progression. Greater toe-out during gait shifts the ground reaction force vector closer to the centre of the knee, reducing the adduction moment. The present study was designed to test whether greater toe-out is associated with lower likelihood of medial OA progression. Methods: Baseline assessments included: kinematic/kinetic gait parameters using an optoelectronic camera system, force platform and inverse dynamics to calculate three-dimensional external knee moments; toe-out angle ( formed by the line connecting heel strike and toe-off plantar surface centres of pressure and the forward progression line; knee pain; and full-limb alignment. Knee x-rays ( semi-flexed) were obtained at baseline and at 18 months, with progression noted as medial joint space grade worsening. With logistic regression, odds ratios (ORs) for progression/5 degrees toe-out were estimated. Results: In the 56 subjects (59% women, mean age 66.6 years, body mass index (BMI) 29), baseline toe-out angle was less in knees with than without progression ( difference-4.4, 95% CI-8.5 to -0.3). Greater toe-out was associated with reduced likelihood of progression ( OR 0.60, 95% CI 0.37 to 0.98). Adjusting for age, gender, BMI, pain severity and disease severity, the OR was 0.62, 95% CI 0.36 to 1.06. Adjusting for adduction moment ( second peak), the OR was 0.72, 95% CI 0.40 to 1.28. Conclusions: Osteoarthritic knees that progressed had less toeing- out than knees without progression. Greater toe-out was associated with a lower likelihood of progression. Adjustment for covariates did not alter the OR, although the 95% CI included 1. Further adjustment for adduction moment did alter the OR, consistent with the possibility that a mechanism of the effect may be via lowering of the adduction moment.
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