Journal
EXPERT REVIEW OF VACCINES
Volume 6, Issue 5, Pages 785-796Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/14760584.6.5.785
Keywords
adjuvant; cationic liposome; DC-Chol; DDA; delivery system; 1,2-dioleoyl-3-trimethylammonium-propane; immunomodulator; vaccine
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Cationic liposomes are lipid-bilayer vesicles with a positive surface charge that have re-emerged as a promising new adjuvant technology. Although there is some evidence that cationic liposomes; themselves can improve the immune response against coadministered vaccine antigens, their main functions are to protect the antigens from clearance in the body and deliver the antigens to professional antigen-presenting cells. In addition, cationic liposomes can be used to introduce immunomodulators to enhance and modulate the immune response in a desirable direction and, thereby, represent an efficient tool when designing tailor-made adjuvants for specific disease targets. In this article we review the recent progress on cationic liposomes as vehicles, enhancing the effect of immunomodulators and the presentation of vaccine antigens.
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