Journal
AGING CELL
Volume 6, Issue 5, Pages 727-729Publisher
WILEY
DOI: 10.1111/j.1474-9726.2007.00328.x
Keywords
gene knock-out; insulin-like growth factor I; longevity; mouse model; pregnancy-associated plasma protein A, tumors
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Genetic deletion in mice of pregnancy-associated plasma protein A (PAPP-A), a recently identified metalloproteinase in the insulin-like growth factor system, extends by 30-40% both mean and maximum lifespan with no reduction in food intake or secondary endocrine abnormalities. Furthermore, these mice have markedly reduced incidence of spontaneous tumors. The findings implicate PAPP-A as a critical regulator of lifespan and age-related diseases, and suggest PAPP-A as a possible target to promote longevity.
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