Journal
LETTERS IN ORGANIC CHEMISTRY
Volume 4, Issue 7, Pages 505-508Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157017807782006245
Keywords
4-thiazolidinone; heterocycles; cyclocondensation
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Several 1,3-thiazolidin-4-ones were synthesized by cyclocondensation reaction of 2-amino-1,3,4-thiadiazole, mercaptoacetic acid and various arenealdehydes in moderate to good yields. These compounds were characterized by I H, C-13 and F-19 NMR. The antimalarial activity of thiazolidinones was evaluated in vitro against Plasmodium falciparum clone but none of them showed activity at maximum concentration (50 mu g/ml) used.
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