Journal
JOURNAL OF DENTAL RESEARCH
Volume 86, Issue 10, Pages 927-936Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/154405910708601005
Keywords
angiogenesis; therapy; blood vessel; cancer; vasculature
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Angiogenesis is the formation of new blood vessels from pre-existing vessels to form capillary networks, which, among other diseases, such as diabetic retinopathy and macular degeneration, is particularly important for tumor growth and metastasis. Thus, depriving a tumor of its vascular supply by means of anti-angiogenic agents has been of great interest since its proposal in the 1970s. This review looks at the common angiogenic inhibitors (angiostatin, endostatin, maspin, pigment epithelium-derived factor, bevacizumab and other monoclonal antibodies, and zoledronic acid) and their current status in clinical trials.
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