Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 19, Issue 5, Pages 529-533Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2007.08.003
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Funding
- NIAID NIH HHS [R01 AI043542, R01 AI044931-10, R01 AI043542-08, R01 AI044931] Funding Source: Medline
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The immunological synapse is a stable adhesive junction between a polarized immune effector cell and an antigen-bearing cell. Immunological synapses are often observed to have a striking radial symmetry in the plane of contact with a prominent central cluster of antigen receptors surrounded by concentric rings of adhesion molecules and actin-rich projections. There is a striking similarity between the radial zones of the immunological synapse and the dynamic actinomyosin modules employed by migrating cells. Breaking the symmetry of an immunological synapse generates a moving adhesive junction that can be defined as a kinapse, which facilitates signal integration by immune cells while moving over the surface of antigen-presenting cells.
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