Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 64, Issue 19-20, Pages 2452-2458Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-007-7277-6
Keywords
adipocyte; fatty acid storage; cholesterol; perilipin; caveolin
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Lipid droplets have been considered for a long time as inert intracytoplasmic deposits formed within cells under various conditions. Recently, new tools and new approaches have been used to visualize and study these intracellular structures. This revealed new aspects of lipid droplets biology and pointed out their organized structure and dynamic composition. In adipocytes, the specialized cell type for the storage of energy as fat, lipid droplets are particularly well-developed organelles and exhibit unique properties. Also discussed in this paper is the view that lipid droplets, through specific candidate constituents, can play a role in sensing the level of their lipid stores by adipocytes.
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