Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 17, Issue 5, Pages 525-532Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2007.08.004
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Funding
- NICHD NIH HHS [R01 HD044752-05, R01 HD044752, HD044752] Funding Source: Medline
- NIMH NIH HHS [R21 MH079198-02, R21 MH079198, MH079198] Funding Source: Medline
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Dendrites exhibit unique cell type-specific branching patterns and targeting specificity that are crucially important for neuronal function and connectivity. Recent evidence indicates that highly complex transcriptional regulatory networks dictate various aspects of dendritic outgrowth, branching, and routing. In addition to other intrinsic molecular pathways such as membrane protein trafficking, interactions between neighboring dendritic branches also contribute to the final specification of dendritic morphology. Nonredundant coverage by dendrites of same type of neurons, known as tiling, requires the actions of the Tricornered/Furry (Sax-1/Sax-2) signaling pathway. However, the dendrites of a neuron do not crossover each other, a process called self-avoidance that is mediated by Down's syndrome cell adhesion molecule (Dscam). Those exciting findings have enhanced significantly our understanding of dendritic morphogenesis and revealed the magnitude of complexity in the underlying molecular regulatory networks.
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