A novel binuclear palladium complex with benzothiazole-2-thiolate: Synthesis, crystal structure and interaction with DNA

The novel Pd(II) complex, [Pd-2(mu-bzta)(4)] 1.5DMSO (where bzta = benzothiazole-2-thiolate) has been synthesized and structurally characterized by element analysis, IR and single-crystal X-ray diffractometry. In the binuclear complex, two palladium(II) are bridged by four deprotonated benzothiazole-2-thialate in a head to tail disposition and the distance of the two Pd(II) is 2.747 angstrom. Three-dimensional structure of the complex was constructed though S center dot center dot center dot S (3.339 angstrom) weak interaction and pi center dot center dot center dot pi stack. The binding of the title complex with fish sperm DNA (FS-DNA) has been investigated by absorption and fluorescence spectra. The results indicate that the complex bind to FS-DNA in an intercalative mode and the intrinsic binding constant K of the title complex with FS-DNA is about 1.2 x 10(4) M-1. Gel electrophoresis assay demonstrates the ability of the complex to cleave the pUC19 plasmid DNA. (C) 2007 Elsevier Inc. All rights reserved.