Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 18, Issue 5-6, Pages 363-371Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2007.06.016
Keywords
double-stranded RNA; RNA interference; innate immunity
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Funding
- NCI NIH HHS [P01 CA62220-11, P01 CA062220, P01 CA062220-11A27336] Funding Source: Medline
- NIAID NIH HHS [R01 AI034039-14, R01 AI34039] Funding Source: Medline
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Double-stranded RNA (dsRNA) has long been recognized as a central component of the interferon (IFN) system. It was originally characterized as a key mediator of IFN induction in response to virus infection. Subsequently, it was identified as a prime activator of the antiviral response. In recent years the discovery of the RNA interference (RNAi) pathway in mammals has renewed interest in dsRNA-mediated cellular responses. This has coincided with the identification of key components of the IFN induction pathway. Here, we present an overview of the current knowledge of dsRNA-mediated pathways in mammalian cells and introduce a link between these pathways and application of RNAi. (c) 2007 Elsevier Ltd. All rights reserved.
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