Journal
BIOESSAYS
Volume 29, Issue 10, Pages 1039-1047Publisher
WILEY
DOI: 10.1002/bies.20647
Keywords
-
Categories
Ask authors/readers for more resources
Both Notch and NF kappa B signaling pathways are well-known for regulating proliferation, differentiation and apoptosis. Recent studies have presented several lines of evidence supporting an integration of the Notch and NF kappa B signaling pathways in differentiation/maturation of a diverse range of cell types. It is notable that Notch and NF kappa B signaling pathways share many common features: (i) both are activated by common stimuli such as TNF-alpha and hypoxia, (ii) activated Notch (NICD) and NF kappa B mediate transcription by regulating corepressors such as SMRT/N-COR, and (iii) both regulate similar target genes such as Hes-1 and I kappa B alpha. This review expands on how the collaboration between these pathways may play an important role in the CNS. We will speculate on the mechanisms by which Notch and NF kappa B signaling may collaborate to regulate stem cell renewal and differentiation during brain development and function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available