Journal
TETRAHEDRON LETTERS
Volume 48, Issue 40, Pages 7129-7133Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2007.07.207
Keywords
water; copper-free; aryl bromides; sonogashira coupling reaction
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A simple, copper-free and efficient catalytic system for the Sonogashira coupling reaction of aryl bromides with terminal alkynes in pure water has been developed. The use of PdCl2/PPh3 in the presence of pyrrolidine allows the coupling reaction to proceed at 120 degrees C in moderate to excellent yields. (c) 2007 Elsevier Ltd. All rights reserved.
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