Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 14, Issue 10, Pages 980-981Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb1299
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CLIP170 and p150(Glued) localize to the plus ends of growing microtubules. Using crystallography and NMR, we show that autoinhibitory interactions within CLIP170 use the same binding determinants as CLIP170's intermolecular interactions with p150Glued. These interactions have both similar and distinct features when compared with the p150(Glued)-EB1 complex. Our data thus demonstrate that regulation of microtubule dynamics by plus end-tracking proteins (+TIPs) occurs through direct competition between homologous binding interfaces.
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