Journal
RHEUMATOLOGY
Volume 46, Issue 10, Pages 1520-1524Publisher
OXFORD UNIV PRESS
DOI: 10.1093/rheumatology/kem147
Keywords
rheumatoid arthritis; MTX; pharmacogenetics
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Methotrexate (MTX) is a cornerstone of therapy for rheumatoid arthritis. However, it is not universally effective and up to one-third of patients fail to respond to treatment, either because of inefficacy or adverse events, although at present it is not possible to predict therapy response accurately. Pharmacogenetics; is the study of variability in drug response due to heredity. MTX has a complex intracellular metabolism and acts via a number of key enzymes. This review critically appraises the studies of MTX pharmacogenetics and highlights the need for further work in this area.
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