Journal
INTEGRATIVE AND COMPARATIVE BIOLOGY
Volume 47, Issue 4, Pages 552-577Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/icb/icm072
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The objective of this symposium at the First International Congress of Respiratory Biology (ICRB) was to enhance communication between comparative biologists and cancer researchers working on O-2 sensing via the HIF pathway. Representatives from both camps came together on August 13-16, 2006, in Bonn, Germany, to discuss molecular adaptations that occur after cells have been challenged by a reduced (hypoxia) or completely absent (anoxia) supply of oxygen. This brief critters-to-cancer survey discusses current projects and new directions aimed at improving understanding of hypoxic signaling and developing therapeutic interventions.
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