Journal
DRUG DISCOVERY TODAY
Volume 12, Issue 19-20, Pages 844-852Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2007.07.020
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Combination devices are at the interface of both pharmaceutical and medical device research. While there have been several notable successes in bringing combination devices to market there are drug selection criteria that both the pharmaceutical and medical device companies need to consider. A successful combination device creates a product that has efficacy greater than the sum of the parts. However, failure to address some aspects of the drug or biologic properties in enough detail could result in a suboptimal product, creating a challenging legacy for future iterations. This review addresses the many dimensions including opportunities and challenges of combination device development from both the device and pharmaceutical perspectives.
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