Conserved mechanisms regulate outgrowth in zebrafish fins

Regulation of size is one of the fundamental problems in One general strategy has been to identify molecules for cell growth and cell proliferation within an has been particularly revealing, identifying cell-autonomous pathways involved in cell growth, survival and In order to identify pathways regulating overall and morphology, experiments have evaluated transplanted and removed tissues, and out genes. This work has provided a vast amount of identifying molecular mechanisms regulating formation, outgrowth, and pattern formation. Using fin, genetic, cellular and molecular strategies been employed to follow both normal patterns of and growth in fin mutants. This review will focus and molecular regulation of the outgrowth and of the zebrafish caudal fin during regeneration, emphasize similarities to other systems. Future describe opportunities using the zebrafish fin to underlying the regulation of final size.