Journal
BIOMOLECULAR ENGINEERING
Volume 24, Issue 4, Pages 415-417Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bioeng.2007.05.003
Keywords
DNA probe engineering; interphase chromosomes; fluorescence in situ hybridization (FISH); multicolor banding (MCB); chromosome instability; nuclear organization
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Biomedical research of interphase chromosomes in their integrity is hindered by technical limitations. We introduce a technology using microdissection-based engineering of DNA probes and fluorescence multicolor chromosome banding that allows studying interaphase chromosome organization, numbers and rearrangements in somatic cells. (c) 2007 Elsevier B.V. All rights reserved.
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