Journal
CLINICAL RHEUMATOLOGY
Volume 26, Issue 10, Pages 1675-1678Publisher
SPRINGER
DOI: 10.1007/s10067-007-0568-3
Keywords
estrogen; estrogen receptor; RQ-PCR; systemic lupus erythematosus
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To investigate the influence of sex hormones on the development of systemic lupus erythematosus (SLE), we examined the estrogen receptor (ER) expression by peripheral blood mononuclear cells (PBMC) in patients with SLE using the real-time quantitative polymerase chain reaction (TaqMan) method. The expression of messenger RNA (mRNA) for ER alpha (ERa) was increased and expression of ER beta (ERb) mRNA was decreased in PBMC from SLE patients compared with PBMC from normal controls. These findings may be useful for elucidation of the pathophysiology of SLE.
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