Journal
GENERAL THORACIC AND CARDIOVASCULAR SURGERY
Volume 55, Issue 10, Pages 431-433Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s11748-007-0154-2
Keywords
Sclerosing mediastinitis; IgG4; Steroid therapy
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Sclerosing mediastinitis is not a common condition in the thoracic cavity and is difficult to cure. Several medications have been used; however, most of the cases do not achieve satisfactory results, and the most successful treatment is operative resection. We report the first case of IgG4-related sclerosing mediastinitis that showed IgG4-positive plasma cells infiltrated into the fibrous tissue and a high serum IgG4 level. The patient clearly showed remission of the symptoms after steroid therapy. Our findings suggest that the serum IgG4 level is a good selection indicator for steroid therapy in sclerosing mediastinitis.
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