Journal
JOURNAL OF VIROLOGY
Volume 81, Issue 20, Pages 11549-11552Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00960-07
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Funding
- NCRR NIH HHS [RR016001, R24 RR016001] Funding Source: Medline
- NIAID NIH HHS [R01 AI040101, AI040101] Funding Source: Medline
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A human immunodeficiency virus type 1 (HIV-1) derivative (HIVNL-DT5R) containing sequences encoding a 7-amino-acid segment of CA and the entire vif gene from simian immunodeficiency virus (SIV) was previously shown to establish spreading infections in cultured macaque peripheral blood mononuclear cells. To assess its replicative and disease-inducing properties in vivo, HIVNL-DT5R was inoculated into pig-tailed macaques. HIVNL-DT5R generated plasma viremia in all five of the monkeys and elicited humoral responses against all of the HfV-1 structural proteins but did not cause CD4(+) T-lymphocyte depletion or clinical disease. Additional adaptation will be required to optimize infectivity in vivo.
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