Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 64, Issue 19-20, Pages 2525-2541Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-007-7188-6
Keywords
CHIP; Parkin; Hsp70; Hsp90; ubiquitin; proteasome
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To be, or not to be - that is the question not only for Hamlet in Shakespeare's drama but also for a protein associated with molecular chaperones. While long viewed exclusively as cellular folding factors, molecular chaperones recently emerged as active participants in protein degradation. This places chaperones at the center of a life or death decision during protein triage. Here we highlight molecular mechanisms that underlie chaperone action at the folding/degradation interface in mammalian cells. We discuss the importance of chaperone-assisted degradation for the regulation of cellular processes and its emerging role as a target for therapeutic intervention in cancer and amyloid diseases.
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