Journal
MOLECULAR BIOLOGY OF THE CELL
Volume 18, Issue 10, Pages 3883-3893Publisher
AMER SOC CELL BIOLOGY
DOI: 10.1091/mbc.E06-09-0818
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Funding
- NINDS NIH HHS [NS59953, R56 NS059953, R01 NS059953-01, NS32196, F32NS10957, R01 NS032196, R01 NS059953, F32 NS010957, R37 NS032196] Funding Source: Medline
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The proline-directed kinase Cdk5 plays a role in several aspects of neuronal development. Here, we show that CDK-5 activity regulates the abundance of the glutamate receptor GLR-1 in the ventral cord of Caenorhabditis elegans and that it produces corresponding changes in GLR-1-dependent behaviors. Loss of CDK-5 activity results in decreased abundance of GLR-1 in the ventral cord, accompanied by accumulation of GLR-1 in neuronal cell bodies. Genetic analysis of cdk-5 and the clathrin adaptin unc-11 AP180 suggests that CDK-5 functions prior to endocytosis at the synapse. The scaffolding protein LIN-10/Mint-1 also regulates GLR-1 abundance in the nerve cord. CDK-5 phosphorylates LIN-10/Mint-1 in vitro and bidirectionally regulates the abundance of LIN-10/Mint-1 in the ventral cord. We propose that CDK-5 promotes the anterograde trafficking of GLR-1 and that phosphorylation of LIN-10 may play a role in this process.
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