Journal
SEMINARS IN CANCER BIOLOGY
Volume 17, Issue 5, Pages 395-402Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2007.06.013
Keywords
tea; inhibition of carcinogenesis; mechanisms for cancer inhibitory activity
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Funding
- NCI NIH HHS [P01 CA088961-05, P01 CA088961] Funding Source: Medline
- NIEHS NIH HHS [P30 ES005022] Funding Source: Medline
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The possible cancer preventive activity of tea has received much attention in recent years. The inhibitory activities of tea and tea constituents against carcinogenesis at different organ sites have been demonstrated in many animal models. The effect of tea consumption on human cancers, however, remains inconclusive. The mechanisms of action of tea polyphenols, especially EGCG, the most abundant and active catechin, have been extensively investigated. Most of the studies, however, were based on cell culture systems, and these mechanisms need to be evaluated and verified in animal models or humans in order to gain more understanding on the effect of tea consumption on human cancer. Human intervention trials are warranted to determine the possible prevention of cancer of specific sites by preparation of tea constituents. (c) 2007 Elsevier Ltd. All rights reserved.
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