Journal
JOURNAL OF CLINICAL GASTROENTEROLOGY
Volume 41, Issue 9, Pages 799-809Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCG.0b013e318033d71d
Keywords
ulcerative colitis; Crohn's disease; 5-ASA; AZA/6-MP; infliximab
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Most physicians believe that the drugs they prescribe will work in their patients and thus have made little preparation for alternative strategies in the event of failure. In the treatment of inflammatory bowel disease (IBD), achieving a remission rate of 20% to 30% or a response rate of 50% to 60% is highly acceptable. This review focuses primarily on placebo-controlled trials that evaluated usual treatments for IBD in terms of induction and maintenance of remission, and identifies the gaps (ie, the percentage of patients lacking any benefit) in currently available treatments for IBD. Approximately, 40% to 60% of patients will not benefit from the available treatments, indicating a considerable unmet need for new, more effective therapies.
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