Journal
EUROPEAN JOURNAL OF PEDIATRICS
Volume 166, Issue 10, Pages 1003-1007Publisher
SPRINGER
DOI: 10.1007/s00431-006-0371-1
Keywords
glucose; hyperinsulinism; gypoglycaemia; insulin; intrauterine growth retardation
Categories
Ask authors/readers for more resources
Newborns with intrauterine growth retardation (IUGR) have multiple risk factors for developing hypoglycaemia. Hyperinsulinism, both transient and prolonged, is one of the major risk factors responsible for the hypoglycaemia observed in some newborns with IUGR. Once the child has progressed beyond the infancy period, the most common cause of hypoglycaemia is ketotic hypoglycaemia. We report our observations of ketotic hypoglycaemia in six children who were born with IUGR and developed hyperinsulinaemic hypoglycaemia (HH) that required treatment with diazoxide and chlorothiazide. In one of these children the ketotic hypoglycaemia was found to be due to growth hormone deficiency; in the remaining five patients, however, no cause for the hypoglycaemia could be found, despite extensive investigations. These observations suggest that ketotic hypoglycaemia may be more common in children with a history of IUGR. Further studies are required to understand why some newborns with IUGR and HH have an increased risk of ketotic hypoglycaemia in childhood. Newborns with a history of IUGR and HH have an increased risk of developing ketotic hypoglycaemia in the childhood period.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available