Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 14, Issue 10, Pages 982-983Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb1301
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Funding
- NIAMS NIH HHS [AR44232, AR42047] Funding Source: Medline
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Eukaryotic elongation factor-1 (eEF1) is essential for peptidechain elongation during translation. We report that its c subunit (eEF1B gamma) specifically binds, and bundles, keratin intermediate filaments. Disrupting this interaction depresses translation by similar to 20% and selectively increases 80S ribosomes in epithelial cells, an outcome recapitulated by RNA interference-mediated silencing of eEF1B gamma. These findings extend the emerging relationship between keratin proteins and the translational machinery.
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