Journal
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
Volume 81, Issue 3, Pages 521-538Publisher
ACAD BRASILEIRA DE CIENCIAS
DOI: 10.1590/S0001-37652009000300016
Keywords
sleep; sleep deprivation; rebound; dopamine; erection; corticosterone; memory
Categories
Funding
- Associacao Fundo de Incentivo a Psicofarmacologia (AFIP)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
- Centros de Pesquisa Inovacao e Difusao (CEPID) [98/14303-3]
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Sleep comprises approximately one-third of a person's lifetime, but its impact on health and medical conditions remains partially unrecognized. The prevalence of sleep disorders is increasing in modern societies, with significant repercussions on people's well-being. This article reviews past and current literature on the paradoxical sleep deprivation method as well as data on its consequences to animals, ranging from behavioral changes to alterations in the gene expression. More specifically, we highlight relevant experimental studies and our group's contribution over the last three decades.
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