Journal
STEM CELLS AND DEVELOPMENT
Volume 16, Issue 5, Pages 797-810Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/scd.2007.0024
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We show here that human and mouse mesenchymal stem cells (MSCs) can be obtained not only from bone marrow ( BM), but also from adult spleen and thymus. In vitro, both human and mouse spleen- and thymus-derived MSCs exhibit immunophenotypic characteristics and differentiation potential completely comparable to BM-MSCs. In addition, they can inhibit immune responses mediated by activated T lymphocytes with efficiency comparable to BM-MSCs. In vivo, mouse MSCs from BM, spleen, and thymus, if injected together with a genetically modified tumor cell vaccine, can equally prevent the onset of an anti-tumor memory immune response, thus leading to tumor growth in normally resistant mice. Our data suggest that not only do spleen and thymus have a stem cell reservoir to build up their stromal architecture, but also contain microenviromental immunoregulatory cells with the same properties of BM-MSCs.
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